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Submit ReviewUPF 648
Description: Potent kynurenine 3-monooxygenase (KMO) inhibitor
Chemical Name: (1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic acid
Purity: ≥98% (HPLC)
Biological Activity for UPF 648
UPF 648 is a potent kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor (IC50 = 20 nM). Increases kynurenic acid levels, and decreases 3-HK and QUIN levels in cerebrum and liver of neonatal rodents. Neuroprotective in a Drosophila model of Huntington's disease.
Technical Data for UPF 648
| M. Wt | 259.09 |
| Formula | C11H8Cl2O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 213400-34-1 |
| PubChem ID | 9859947 |
| InChI Key | ZBRKMOHDGFGXLN-BQBZGAKWSA-N |
| Smiles | [H][C@]1([C@@H]([C@](O)=O)C1)C(C2=CC=C(Cl)C(Cl)=C2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UPF 648
References for UPF 648
References are publications that support the biological activity of the product.
Ceresoli-Borroni et al (2007) Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. J.Neurosci.Res. 85 845 PMID: 17279543
Amaral et al (2013) Structural basis of kynurenine 3-monooxygenase inhibition. Nature 496 382 PMID: 23575632
Amori et al (2009) On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J.Neurochem. 109 316 PMID: 19226371
Campesan et al (2011) The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease. Curr.Biol. 21 961 PMID: 21636279
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Keywords: UPF 648, UPF 648 supplier, UPF648, potent, kynurenine, 3-monooxygenase, 3-hydroxylase, KMO, inhibitors, inhibits, huntington's, disease, KYNA, 3-hk, QUIN, neuroprotective, Hydroxylases, Kynurenine, 4926, Tocris Bioscience
1 Citation for UPF 648
Citations are publications that use Tocris products. Selected citations for UPF 648 include:
NULL et al (2020) ACNP 59th annual meeting: panels, mini-panels and study groups. Neuropsychopharmacology 45 24473 PMID: 33279933
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Multiple Sclerosis Poster
Multiple sclerosis (MS) is an autoimmune disease that is characterized by focal demyelination and axon degeneration in the central nervous system. This poster summarizes the neurobiology and current therapies of MS.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.