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Description: Selective and competitive urotensin II receptor antagonist
Alternative Names: [Pen5,DTrp7,Orn8]hU-II(4-11)
Biological Activity for Urantide
Urantide is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acetylcholine-induced relaxation. Behaves as a partial agonist in a calcium mobilization assay (in CHO cells expressing hUT receptors).
Technical Data for Urantide
| M. Wt | 1075.26 |
| Formula | C51H66N10O12S2 |
| Sequence | DXFWXYCV(Modifications: X-2 = Pen, X-5 = Orn, Trp-4 = D-Trp, Disulfide bridge: 2-7) |
| Storage | Store at -20°C |
| CAS Number | 669089-53-6 |
| PubChem ID | 11520939 |
| InChI Key | VXLUBANOZQJZFE-QVKHRKAHSA-N |
| Smiles | CC(C)[C@H](NC(=O)[C@@H]1CSSC(C)(C)[C@@H](NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Urantide
References for Urantide
References are publications that support the biological activity of the product.
Patacchini et al (2003) Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta. Br.J.Pharmacol. 140 1155 PMID: 14645137
Carotenuto et al (2014) Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. J.Med.Chem. 57 5965 PMID: 24992374
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Keywords: Urantide, Urantide supplier, Selective, competitive, urotensin, II, antagonists, [Pen5,DTrp7,Orn8]hU-II(4-11), Urotensin-II, Receptors, 5296, Tocris Bioscience
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