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Submit ReviewUrapidil hydrochloride
Discontinued Product
1772 has been discontinued.
View all Adrenergic α<sub>1</sub> Receptors products.
Description: α1 antagonist; also 5-HT1A receptor agonist
Chemical Name: 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Urapidil hydrochloride
Urapidil hydrochloride is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist (pIC50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.
Technical Data for Urapidil hydrochloride
| M. Wt | 423.94 |
| Formula | C20H29N5O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 64887-14-5 |
| PubChem ID | 167980 |
| InChI Key | KTMLZVUAXJERAT-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC=CC=C1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Urapidil hydrochloride
References for Urapidil hydrochloride
References are publications that support the biological activity of the product.
Gross et al (1987) Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for α1-adrenoceptor binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 336 597 PMID: 2832770
Kolassa et al (1989) Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil. Am.J.Cardiol. 64 7D PMID: 2569265
van Zwieten PA (1989) Pharmacologic profile of urapidil. Am.J.Cardiol. 64 1D PMID: 2569262
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Citations for Urapidil hydrochloride
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Currently there are no citations for Urapidil hydrochloride.
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Literature in this Area
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.