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Submit ReviewURB 602
Description: Non-competitive MAGL inhibitor
Chemical Name: N-[1,1'-Biphenyl]-3-yl-carbamic acid cyclohexyl ester
Purity: ≥99% (HPLC)
Biological Activity for URB 602
URB 602 is a non-competitive MAGL inhibitor. Exhibits selectivity for MAGL over FAAH, diacylglycerol lipase and COX2. Blocks 2-AG hydrolysis in rat brain slices. Enhances stress-induced analgesia in rats.
Technical Data for URB 602
| M. Wt | 295.38 |
| Formula | C19H21NO2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 565460-15-3 |
| PubChem ID | 10979337 |
| InChI Key | HHVUFQYJOSFTEH-UHFFFAOYSA-N |
| Smiles | O=C(OC1CCCCC1)NC2=CC=CC(C3=CC=CC=C3)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for URB 602
References for URB 602
References are publications that support the biological activity of the product.
Hohmann et al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature. 435 1108 PMID: 15973410
Makara et al (2005) Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat.Neurosci. 8 1139 PMID: 16116451
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Keywords: URB 602, URB 602 supplier, URB602, non-competitive, MAGL, inhibitors, inhibits, monoacylglycerol, lipases, 6020, Tocris Bioscience
Citations for URB 602
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