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Submit ReviewUrocortin (human)
Description: Endogenous CRF agonist
Purity: ≥95% (HPLC)
Biological Activity for Urocortin (human)
Urocortin (human) is an endogenous CRF agonist. Ki values are 0.4, 0.3 and 0.5 nM for hCRF1, rCRF2α and mCRF2β respectively.
Licensing Information
Sold with the permission of the SALK Institute
Technical Data for Urocortin (human)
| M. Wt | 4696.29 |
| Formula | C204H337N63O64 |
| Sequence |
DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV (Modifications: Val-40 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 176591-49-4 |
| PubChem ID | 24868180 |
| InChI Key | BIIOOWPFSOAZSO-WODJFTBTSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Urocortin (human)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Urocortin (human)
References for Urocortin (human)
References are publications that support the biological activity of the product.
Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312 PMID: 10816663
Reul and Holsboer (2002) Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr.Opin.Pharmacol. 2 23 PMID: 11786305
Skelton et al (2000) The neurobiology of urocortin. Regul.Pept. 93 85 PMID: 11033056
If you know of a relevant reference for Urocortin (human), please let us know.
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Keywords: Urocortin (human), Urocortin (human) supplier, Endogenous, CRF, agonists, Corticotropin-Releasing, Factor, Non-Selective, Receptors, Non-selective, 1604, Tocris Bioscience
Citations for Urocortin (human)
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Literature in this Area
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.