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V 9302 hydrochloride

Cat. No. 8057 Submit a Review Datasheet / COA / SDS
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Description: ASCT2 (SLC1A5) inhibitor
Chemical Name: (2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid hydrochloride
Purity: ≥97% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for V 9302 hydrochloride

V 9302 hydrochloride is an alanine-serine-cysteine transporter 2 (ASCT2, encoded by gene SLC1A5) inhibitor. It inhibits glutamate uptake (IC50 = 9.6 μM in HEK-293 cells). It reduces cancer cell growth and proliferation, also increases cell death and oxidative stress in vitro and in vivo. V 9302 hydrochloride inhibits mTORC1 activity, mitochondrial respiration, proliferation and migration of vascular smooth muscle cells (VSMCs).

Licensing Information

Sold under license from Vanderbilt University

Technical Data for V 9302 hydrochloride

M. Wt 575.15
Formula C34H38N2O4.HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 2416138-42-4
PubChem ID 145710038
InChI Key LUQMUDMPRZSZTJ-YNMZEGNTSA-N
Smiles CC1=CC=CC(COC(C=CC=C2)=C2CN(CC[C@H](N)C(O)=O)CC3=C(C=CC=C3)OCC4=CC(C)=CC=C4)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for V 9302 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.76 50 with gentle warming
ethanol 28.76 50 with gentle warming

Preparing Stock Solutions for V 9302 hydrochloride

The following data is based on the product molecular weight 575.15. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.48 mL 17.39 mL 34.77 mL
2.5 mM 0.7 mL 3.48 mL 6.95 mL
5 mM 0.35 mL 1.74 mL 3.48 mL
25 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets for V 9302 hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for V 9302 hydrochloride

References are publications that support the biological activity of the product.

Schulte et al (2018) Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat.Med. 24 194 PMID: 29334372

Park et al (2021) V-9302 inhibits proliferation and migration of VSMCs, and reduces neointima formation in mice after carotid artery ligation. Biochem.Biophys.Res.Commun. 560 45 PMID: 33965788

Li et al (2022) Inhibitor of glutamine metabolism V9302 promotes ROSinduced autophagic degradation of B7H3 to enhance antitumor immunity. J.Biol.Chem. 298 101753 PMID: 35189139

If you know of a relevant reference for V 9302 hydrochloride, please let us know.

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Citations for V 9302 hydrochloride

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