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Submit ReviewVeratridine
Description: Voltage-gated Na+ channel opener
Chemical Name: 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol
Purity: ≥98% (HPLC)
Biological Activity for Veratridine
Veratridine is a voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.
Technical Data for Veratridine
| M. Wt | 673.79 |
| Formula | C36H51NO11 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 71-62-5 |
| PubChem ID | 6280 |
| InChI Key | FVECELJHCSPHKY-YFUMOZOISA-N |
| Smiles | O=C(C8=CC=C(OC)C(OC)=C8)O[C@H]1CC[C@@]2(C)[C@@]3([H])[C@@](O)1O[C@@]42[C@@]([C@@](C[C@H](O)[C@@]6(O)[C@]([H])5CN7[C@](CC[C@H](C)C7)([H])[C@@](O)6C)(O)[C@@]5(O)C4)([H])CC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Veratridine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.69 | 50 |
Preparing Stock Solutions for Veratridine
The following data is based on the product molecular weight 673.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.97 mL | 14.84 mL | 29.68 mL |
| 2.5 mM | 0.59 mL | 2.97 mL | 5.94 mL |
| 5 mM | 0.3 mL | 1.48 mL | 2.97 mL |
| 25 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets for Veratridine
References for Veratridine
References are publications that support the biological activity of the product.
McKinney et al (1986) Purification, solubility and pKa of veratridine. Anal.Biochem. 153 33 PMID: 3963380
Maroto et al (1994) Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine. Eur.J.Pharmacol. 270 331 PMID: 7805782
Fekete et al (2009) Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation: implication for epilepsy. J.Neurochem. 111 745 PMID: 19719824
If you know of a relevant reference for Veratridine, please let us know.
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Keywords: Veratridine, Veratridine supplier, Sodium, channel, opener, neutoxin, Na+, Na, voltage-gated, ion, channels, neurotoxins, Voltage-gated, Channels, 2918, Tocris Bioscience
6 Citations for Veratridine
Citations are publications that use Tocris products. Selected citations for Veratridine include:
Bedut et al (2016) High-throughput drug profiling with voltage- and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes. Am J Physiol Heart Circ Physiol 311 H44 PMID: 27199128
Battefeld et al (2016) Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Biol Psychiatry 7 11298 PMID: 27161034
Jones et al (2014) Human macrophage SCN5A activates an innate immune signaling pathway for antiviral host defense. J Biol Chem 289 35326 PMID: 25368329
McKeithan et al (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 8 766 PMID: 29075196
Agarwal et al (2017) Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 93 587 PMID: 28132831
Malmersjö et al (2013) Neural progenitors organize in small-world networks to promote cell proliferation. Nat Commun 110 E1524 PMID: 23576737
Do you know of a great paper that uses Veratridine from Tocris? Please let us know.
Reviews for Veratridine
Average Rating: 5 (Based on 2 Reviews.)
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Voltage sensitive sodium channel opening.
By
Anonymous on 11/19/2018
Assay Type: Ex Vivo
Species: Mouse
Can be used to activate and open voltage sensitive sodium channels in neurons. Elicits rapid reaction when applied directly to tissue.
Increases intracellular Na+ and tissue swelling.
By
Anonymous on 05/02/2018
Assay Type: Ex Vivo
Species: Rat
Verstridine is a voltage-gated sodium channel agonist. It increases intracellular Na+ concentration and also induces cellular and tissue swelling. We used at 50 microM to rat brain slices.