Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewVH 032, propargyl
Description: Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs
Chemical Name: (2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(prop-2-yn-1-yloxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥95% (HPLC)
Biological Activity for VH 032, propargyl
VH 032, propargyl is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand with terminal propargyl ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for VH 032, propargyl
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for VH 032, propargyl
| M. Wt | 526.65 |
| Formula | C27H34N4O5S |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2098799-78-9 |
| Smiles | CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(COCC#C)=O)=O)O)=O)SC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VH 032, propargyl
References for VH 032, propargyl
References are publications that support the biological activity of the product.
Wurz et al (2018) A "click chemistry platform" for the rapid synthesis of bispecific molecules for inducing protein degradation. J.Med.Chem. 61 453 PMID: 28378579
If you know of a relevant reference for VH 032, propargyl, please let us know.
View Related Products by Target
Keywords: VH 032, propargyl, VH 032, propargyl supplier, VH032,, propargyl, Proteolysis, Targeting, Chimera, PROTACs, VHL, E3, ubiquitin, ligase, conjugate, PROTAC, polyethene, glycol, von-Hippel-Lindau, protein, ligand, terminal, Functionalized, Ligase, Ligands, 6683, Tocris Bioscience
Citations for VH 032, propargyl
Citations are publications that use Tocris products.
Currently there are no citations for VH 032, propargyl. Do you know of a great paper that uses VH 032, propargyl from Tocris? Please let us know.
Reviews for VH 032, propargyl
There are currently no reviews for this product. Be the first to review VH 032, propargyl and earn rewards!
Have you used VH 032, propargyl?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia