Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewVismodegib
Description: Potent hedgehog pathway inhibitor
Chemical Name: 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide
Purity: ≥98% (HPLC)
Biological Activity for Vismodegib
Vismodegib is a potent hedgehog pathway inhibitor (IC50 = 3 nM). It causes tumor regressions in allograft medulloblastoma mice model and tumor growth inhibition in a xenograft mouse models of colorectal cancer. Vismodegib is orally bioavailable.
Technical Data for Vismodegib
| M. Wt | 421.3 |
| Formula | C19H14Cl2N2O3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 879085-55-9 |
| PubChem ID | 24776445 |
| InChI Key | BPQMGSKTAYIVFO-UHFFFAOYSA-N |
| Smiles | O=C(NC=1C=CC(Cl)=C(C1)C2=NC=CC=C2)C3=CC=C(C=C3Cl)S(=O)(=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Vismodegib
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.13 | 100 |
Preparing Stock Solutions for Vismodegib
The following data is based on the product molecular weight 421.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.87 mL | 23.74 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.75 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Vismodegib
References for Vismodegib
References are publications that support the biological activity of the product.
Robarge et al (2009) GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg.Med.Chem.Lett. 19 5576 PMID: 19716296
Wong et al (2009) Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor. Xenobiotica 39 850 PMID: 19845436
Wong et al (2011) Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation. Clin.Cancer Res. 17 4682 PMID: 21610148
If you know of a relevant reference for Vismodegib, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Vismodegib, Vismodegib supplier, potent, inhibitors, hedgehog, Hh, pathway, signaling, inhibits, Signalling, orally, bioavailable, Hedgehog, Signaling, 7710, Tocris Bioscience
Citations for Vismodegib
Citations are publications that use Tocris products.
Currently there are no citations for Vismodegib. Do you know of a great paper that uses Vismodegib from Tocris? Please let us know.
Reviews for Vismodegib
There are currently no reviews for this product. Be the first to review Vismodegib and earn rewards!
Have you used Vismodegib?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.