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Submit ReviewVU 0238429
Description: Selective positive allosteric modulator of M5 receptors
Chemical Name: 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin
Purity: ≥97% (HPLC)
Biological Activity for VU 0238429
VU 0238429 is a selective positive allosteric modulator of M5 receptors (EC50 values are 1.16, >30 and >30 μM at M5, M1 and M3 receptors respectively). Displays no activity at M2 and M4 receptors.
Compound Libraries for VU 0238429
VU 0238429 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for VU 0238429
| M. Wt | 351.28 |
| Formula | C17H12F3NO4 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1160247-92-6 |
| PubChem ID | 42633508 |
| InChI Key | CKLGZXFOLMHCMC-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC(OC(F)(F)F)=CC=C1N2CC3=CC=C(OC)C=C3)C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VU 0238429
References for VU 0238429
References are publications that support the biological activity of the product.
Bridges et al (2009) Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J.Med.Chem. 52 3445 PMID: 19438238
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Keywords: VU 0238429, VU 0238429 supplier, Selective, positive, allosteric, modulators, PAMs, M5, receptors, Muscarinic, Acetylcholine, Ach, VU0238429, Receptors, 3634, Tocris Bioscience
Citations for VU 0238429
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Currently there are no citations for VU 0238429.
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