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Submit ReviewVU 0357121
Discontinued Product
4437 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
Description: Positive allosteric modulator of mGlu5 receptors
Chemical Name: 4-Butoxy-N-(2,4-difluorophenyl)benzamide
Purity: ≥99% (HPLC)
Biological Activity for VU 0357121
VU 0357121 is a positive allosteric modulator of mGlu5 receptors (EC50 = 33 nM). Binds to a site distinct from that bound by MPEP (Cat. No. 1212).
Technical Data for VU 0357121
| M. Wt | 305.32 |
| Formula | C17H17F2NO2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 433967-28-3 |
| PubChem ID | 2296132 |
| InChI Key | AHCYOTLTLQTPSU-UHFFFAOYSA-N |
| Smiles | O=C(NC2=C(F)C=C(F)C=C2)C1=CC=C(OCCCC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VU 0357121
References for VU 0357121
References are publications that support the biological activity of the product.
Hammond et al (2010) Discovery of a novel chemical class of mGlu5 allosteric ligands with distinct modes of pharmacology. ACS Chem.Neurosci. 1 702 PMID: 20981342
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Keywords: VU 0357121, VU 0357121 supplier, VU0357121, pams, positive, allosteric, modulators, mglu5, receptors, mglur5, Glutamate, (Metabotropic), Group, I, Receptors, 4437, Tocris Bioscience
Citations for VU 0357121
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Currently there are no citations for VU 0357121.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.