Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewVU 0364739 hydrochloride
Description: Potent and selective PLD2 inhibitor
Chemical Name: N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for VU 0364739 hydrochloride
VU 0364739 hydrochloride is a potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM); displays 75-fold selectivity against PLD1 (IC50 = 1500 nM).
Compound Libraries for VU 0364739 hydrochloride
VU 0364739 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for VU 0364739 hydrochloride
| M. Wt | 482.98 |
| Formula | C26H27FN4O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1244640-48-9 |
| PubChem ID | 46939225 |
| InChI Key | RYLAMDMOILNBKN-UHFFFAOYSA-N |
| Smiles | O=C(NCCN3CCC(C(NCN4C5=CC(F)=CC=C5)=O)4CC3)C2=CC1=CC=CC=C1C=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for VU 0364739 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.3 | 100 |
Preparing Stock Solutions for VU 0364739 hydrochloride
The following data is based on the product molecular weight 482.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.07 mL | 10.35 mL | 20.7 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.14 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.07 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for VU 0364739 hydrochloride
References for VU 0364739 hydrochloride
References are publications that support the biological activity of the product.
Lavieri et al (2010) Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J.Med.Chem. 53 6709
If you know of a relevant reference for VU 0364739 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: VU 0364739 hydrochloride, VU 0364739 hydrochloride supplier, VU0364739, hydrochloride, phospholipases, d1, d2, potent, selective, inhibitors, inhibits, pld2, Phospholipases, 4171, Tocris Bioscience
10 Citations for VU 0364739 hydrochloride
Citations are publications that use Tocris products. Selected citations for VU 0364739 hydrochloride include:
Basiouni et al (2013) The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells. Autophagy 14 9005 PMID: 23698760
Xiao-Fan et al (2022) Parkin coordinates mitochondrial lipid remodeling to execute mitophagy. EMBO Rep 23 e55191 PMID: 36256516
Martínez-Martínez et al (2014) Phospholipase D2 is involved in the formation of Golgi tubules and ArfGAP1 recruitment. PLoS One 9 e111685 PMID: 25354038
Liu et al (2017) PLD2 regulates microtubule stability and spindle migration in mouse oocytes during meiotic division. PeerJ 5 e3295 PMID: 28533957
Chelakkot et al (2017) Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin. Sci Rep 7 1573 PMID: 28484281
Krishnan et al (2018) Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits. Alzheimer Dement (N Y) 4 89 PMID: 29560412
Jiang et al (2016) Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells. J Biol Chem. 291 20729 PMID: 27510034
Tove Irene et al (2021) Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus. Cell Mol Life Sci 78 985-1009 PMID: 32447426
Bich et al (2018) Physiological function of phospholipase D2 in anti-tumor immunity: regulation of CD8+ T lymphocyte proliferation. Sci Rep 8 6283 PMID: 29674728
Lu et al (2018) An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets. J Clin Med 7 PMID: 30441821
Do you know of a great paper that uses VU 0364739 hydrochloride from Tocris? Please let us know.
Reviews for VU 0364739 hydrochloride
There are currently no reviews for this product. Be the first to review VU 0364739 hydrochloride and earn rewards!
Have you used VU 0364739 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image