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Submit ReviewVU 0364770
Discontinued Product
4469 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
Description: Positive allosteric modulator of mGlu4 receptors
Chemical Name: N-(3-Chlorophenyl)-2-pyridinecarboxamide
Purity: ≥99% (HPLC)
Biological Activity for VU 0364770
VU 0364770 is a positive allosteric modulator at mGlu4 receptors (EC50 = 290 nM in mGlu4-expressing HEK 293 cells). Reverses haloperidol-induced catalepsy in rats; prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Exhibits affinity for MAO-B and MAO-A (Ki values are 0.72 μM and 8.5 μM respectively). Brain penetrant.
Technical Data for VU 0364770
| M. Wt | 232.67 |
| Formula | C12H9ClN2O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 61350-00-3 |
| PubChem ID | 836002 |
| InChI Key | SUYUTNCKIOLMAJ-UHFFFAOYSA-N |
| Smiles | O=C(C2=NC=CC=C2)NC1=CC=CC(Cl)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VU 0364770
References for VU 0364770
References are publications that support the biological activity of the product.
Jones et al (2012) The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J.Pharmacol.Exp.Ther. 340 404 PMID: 22088953
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Keywords: VU 0364770, VU 0364770 supplier, VU0364770, glutamate, receptor, Glu, mGlu4, mGluR4, postive, allosteric, modulators, pams, brain, penetrant, Glutamate, (Metabotropic), Group, III, Receptors, 4469, Tocris Bioscience
Citations for VU 0364770
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Currently there are no citations for VU 0364770.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.