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Submit ReviewVU 0365114
Description: Positive allosteric modulator of M5 receptors
Chemical Name: 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
Purity: ≥98% (HPLC)
Biological Activity for VU 0365114
VU 0365114 is a selective positive allosteric modulator of M5 (EC50 values are 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4 receptors).
Technical Data for VU 0365114
| M. Wt | 397.35 |
| Formula | C22H14F3NO3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1208222-39-2 |
| PubChem ID | 45281794 |
| InChI Key | SPBGRXOPAXZSER-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC(OC(F)(F)F)=CC=C1N2CC3=CC=C(C4=CC=CC=C4)C=C3)C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VU 0365114
References for VU 0365114
References are publications that support the biological activity of the product.
Bridges et al (2010) Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: development of the first highly selective M5 PAM. Bioorg.Med.Chem.Lett. 20 558 PMID: 20004578
Bridges et al (2010) Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg.Med.Chem.Lett. 20 5617 PMID: 20801651
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Keywords: VU 0365114, VU 0365114 supplier, VU0365114, acetylcholine, muscarinics, machrs, receptors, positive, allosteric, modulators, pams, m5, M5, Receptors, 4404, Tocris Bioscience
Citations for VU 0365114
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