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VU 0422288

Cat. No. 5378 Submit a Review Datasheet / COA / SDS
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Description: Selective positive allosteric modulator of group III mGlu receptors
Alternative Names: ML 396
Chemical Name: N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for VU 0422288

VU 0422288 is a group III mGlu receptor positive allosteric modulator (EC50 values are 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7 respectively). Exhibits selectivity over a panel of 68 other GPCRs, ion channels and transporters. Potentiates mGlu7-mediated reductions in excitatory post synaptic potentials in hippocampal slices.

Technical Data for VU 0422288

M. Wt 360.19
Formula C17H11Cl2N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1630936-95-6
PubChem ID 73058507
InChI Key MZRLPXFGQKQHST-UHFFFAOYSA-N
Smiles ClC1=CC(NC(C3=CC=CC=N3)=O)=CC=C1OC2=CC=C(Cl)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VU 0422288

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.02 100

Preparing Stock Solutions for VU 0422288

The following data is based on the product molecular weight 360.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.78 mL 13.88 mL 27.76 mL
5 mM 0.56 mL 2.78 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.78 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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References for VU 0422288

References are publications that support the biological activity of the product.

Jalan-Sakrikar et al (2014) Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem.Neurosci. 5 1221 PMID: 25225882

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Citations for VU 0422288

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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