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Submit ReviewVU 152100
Description: Positive allosteric modulator of M4 receptors
Alternative Names: ML 108
Chemical Name: 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide
Purity: ≥98% (HPLC)
Biological Activity for VU 152100
VU 152100 is a selective positive allosteric modulator of M4 muscarinic acetylcholine receptors (mAChRs) (EC50 = 380 nM). Induces 21-fold shift in ACh potency at M4 receptor. Displays no activity at other mAChR subtypes.
Compound Libraries for VU 152100
VU 152100 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for VU 152100
| M. Wt | 341.43 |
| Formula | C18H19N3O2S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 409351-28-6 |
| PubChem ID | 864492 |
| InChI Key | MDNWGCQSCGNTKH-UHFFFAOYSA-N |
| Smiles | CC1=C2C(SC(C(NCC3=CC=C(OC)C=C3)=O)=C2N)=NC(C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for VU 152100
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.07 | 50 |
Preparing Stock Solutions for VU 152100
The following data is based on the product molecular weight 341.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.86 mL | 29.29 mL | 58.58 mL |
| 2.5 mM | 1.17 mL | 5.86 mL | 11.72 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.86 mL |
| 25 mM | 0.12 mL | 0.59 mL | 1.17 mL |
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Product Datasheets for VU 152100
References for VU 152100
References are publications that support the biological activity of the product.
Brady et al (2008) Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J.Pharmacol.Exp.Ther. 327 941 PMID: 18772318
If you know of a relevant reference for VU 152100, please let us know.
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Keywords: VU 152100, VU 152100 supplier, muscarinic, receptors, mAChR, M4, acetylcholine, ACh, selective, positive, allosteric, modulators, VU152100, PAM, ML, 108, ML_108, ML108, Receptors, 3383, Tocris Bioscience
Citations for VU 152100
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