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Submit ReviewVU 6028418 hydrochloride is a potent and selective M4 mAChR antagonist (IC50 = 4.1 nM and 57 nM for human and rat M4 respectively). VU 6028418 hydrochloride dose-dependently reduces the latency to withdraw and reverses cataleptic behavior in haloperidol-treated animals. Orally bioavailable.
Sold under license from Vanderbilt University
M. Wt | 468.95 |
Formula | C23H27F3N4O.HCl |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
InChI Key | IQDWZBQDZTVTLN-NESBVOEXSA-N |
Smiles | [H][C@]12C[C@H](NC3=CC=C(C4=C(C(F)=CC(F)=C4)F)N=N3)C[C@]1(CN(C2)CC5CCOCC5)[H].Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 46.9 | 100 | |
ethanol | 23.45 | 50 |
The following data is based on the product molecular weight 468.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.13 mL | 10.66 mL | 21.32 mL |
5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
10 mM | 0.21 mL | 1.07 mL | 2.13 mL |
50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
References are publications that support the biological activity of the product.
Spock et al (2021) Discovery of VU6028418: a highly selective and orally bioavailable M4 muscarinic acetylcholine receptor antagonist. ACS Med.Chem.Lett. 12 1342 PMID: 34413964
If you know of a relevant reference for VU 6028418 hydrochloride, please let us know.
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