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Submit ReviewW-84 dibromide
Description: Stabilizer of cholinergic antagonist-receptor complexes
Chemical Name: Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide
Biological Activity for W-84 dibromide
W-84 dibromide is a stabilizes cholinergic antagonist-receptor complexes by an allosteric effect. Increases the protective effect of atropine against organophosphate poisoning.
Technical Data for W-84 dibromide
| M. Wt | 708.53 |
| Formula | C32H44Br2N4O4 |
| Storage | Store at RT |
| CAS Number | 21093-51-6 |
| PubChem ID | 167961 |
| InChI Key | DZRJZDQAGMZGGA-UHFFFAOYSA-L |
| Smiles | O=C1N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN(C(C4=C3C=CC=C4)=O)C3=O)C(C2=C1C=CC=C2)=O.[Br-].[Br-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for W-84 dibromide
References for W-84 dibromide
References are publications that support the biological activity of the product.
Jepsen et al (1988) Allosteric stabilisation of [3H]-N-methylscopolamine binding in guinea pig myocardium by an antidote against organophosphate intoxication. Pharmacol.Toxicol. 63 163 PMID: 3054859
Mitchelson (1975) Antimuscarinic action of an alkane-bis ammonium compound alone and in combination with (+)-bensetimide. Eur.J.Pharmacol. 33 237 PMID: 1242377
Mohr et al (1992) Equipotent allosteric effect of W84 on [3H]-NMS binding to cardiac muscarinic receptors from guinea-pig, rat and pig. Pharmacol.Toxicol. 70 198 PMID: 1579545
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Keywords: W-84 dibromide, W-84 dibromide supplier, antagonists-receptor, complex, stabilizer, Muscarinic, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, 0532, Tocris Bioscience
Citations for W-84 dibromide
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Reviews for W-84 dibromide
Average Rating: 4 (Based on 1 Review.)
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HPLC Pharmacokinetic assay.
By
Abhijit Nirwane on 01/10/2018
Assay Type: In Vivo
Species: Mouse
Purity is excellent.
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