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Submit Reviewω-Conotoxin MVIIC
Description: CaV2.x blocker
Biological Activity for ω-Conotoxin MVIIC
ω-Conotoxin MVIIC is a peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.
Licensing Information
Sold under license from the University of Utah.
Technical Data for ω-Conotoxin MVIIC
| M. Wt | 2749 |
| Formula | C106H178N40O32S7 |
| Sequence |
CKGKGAPCRKTMYDCCSGSCGRRGKC (Modifications: Disulfide bridges: 1-16, 8-20, 15-26, Cys-26 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 147794-23-8 |
| PubChem ID | 90479752 |
| InChI Key | FHVUTHWUIUXZBY-IXEXBNPISA-N |
| Smiles | [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]4CCCN4C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NC([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N3)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC2=O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ω-Conotoxin MVIIC
References for ω-Conotoxin MVIIC
References are publications that support the biological activity of the product.
Hillyard et al (1992) A new conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron 9 69 PMID: 1352986
McDonough et al (1996) Inhibition of Ca2+ channels in rat central and peripheral neurons by ω-conotoxin MVIIC. J.Neurosci. 16 2612 PMID: 8786437
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Keywords: w-Conotoxin MVIIC, w-Conotoxin MVIIC supplier, Ca2+, channel, blockers, N-type, P-type, Q-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, omega-Conotoxin, ω-conotoxin, MVIIC, neurotoxins, venoms, Cav2.x, 1084, Tocris Bioscience
11 Citations for ω-Conotoxin MVIIC
Citations are publications that use Tocris products. Selected citations for ω-Conotoxin MVIIC include:
Smith et al (2013) Comparative functional expression of nAChR subtypes in rodent DRG neurons. Front Cell Neurosci 7 225 PMID: 24348328
Hanlon et al (2016) Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent. Breast Cancer (Dove Med Press) 8 59 PMID: 27186076
Schöbel et al (2014) Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds. Chem Senses 39 471 PMID: 24718416
Maier et al (2010) Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem 285 35606 PMID: 20826795
Pascual-Caro et al (2018) STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry. J Mol Med (Berl) 96 1061 PMID: 30088035
Fortalezas et al (2018) Methyl-β-Cyclodextrin Impairs the Phosphorylation of the β2 Subunit of L-Type Calcium Channels and Cytosolic Calcium Homeostasis in Mature Cerebellar Granule Neurons. Int J Mol Sci 19 PMID: 30463327
Luca et al (2017) Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents. Neuron 95 63 PMID: 28683270
Haeberle et al (2008) Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells. Nat Commun 3 e1750 PMID: 18454189
Hashiguchi (2017) Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS One 12 e0184261 PMID: 28877214
Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. PLoS One 350 290 PMID: 24891452
Schöbel et al (2012) Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses. PLoS One 7 e48005 PMID: 23144843
Reviews for ω-Conotoxin MVIIC
Average Rating: 4.5 (Based on 2 Reviews.)
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Suppression of a whole neuron response.
By
Anonymous on 06/21/2023
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Cerebellum
omega -Conotoxin MVIIC in combination with tetrodotoxin was used to clear stimulation artifact from whole-cell electrophysiological response of cerebellar granule cell. Top trace: control response; bottom trace: conotoxin (10 nM) + omega -Conotoxin MVIIC (1 microM) added to perfusion solution.
breast cancer cell viability by a cannabinoid receptor 2 agonist.
By
Anonymous on 03/15/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: MCF-7
We used all these compounds which were dissolved in DMSO and added to fresh culture media. Concentration reference paper PMID: 27186076
