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Submit ReviewWAY 208466 dihydrochloride
Description: Selective 5-HT6 agonist
Chemical Name: 3-[(-3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for WAY 208466 dihydrochloride
WAY 208466 dihydrochloride is a high affinity, selective 5-HT6 agonist (EC50 = 7.3 nM at the human 5-HT6 receptor). Elevates cortical GABA levels in vivo in rat frontal cortex. Exhibits antidepressant and anxiolytic-like effects.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for WAY 208466 dihydrochloride
WAY 208466 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for WAY 208466 dihydrochloride
| M. Wt | 420.33 |
| Formula | C17H18FN3O2S.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1207064-61-6 |
| PubChem ID | 22028182 |
| InChI Key | BAOHMLBVCLITHA-UHFFFAOYSA-N |
| Smiles | O=S(C2=CN(CCN(C)C)C1=NC=CC=C12)(C3=CC=CC(F)=C3)=O.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WAY 208466 dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.63 | 80 | |
| DMSO | 33.63 | 80 |
Preparing Stock Solutions for WAY 208466 dihydrochloride
The following data is based on the product molecular weight 420.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.8 mM | 2.97 mL | 14.87 mL | 29.74 mL |
| 4 mM | 0.59 mL | 2.97 mL | 5.95 mL |
| 8 mM | 0.3 mL | 1.49 mL | 2.97 mL |
| 40 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets for WAY 208466 dihydrochloride
References for WAY 208466 dihydrochloride
References are publications that support the biological activity of the product.
Schechter et al (2008) Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacol 33 1323 PMID: 17625499
Carr et al (2010) Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacol.(Berl.) 213 49 PMID: 20217056
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Keywords: WAY 208466 dihydrochloride, WAY 208466 dihydrochloride supplier, WAY208466, 2HCl, serotonin, receptor, subtype, 5-hydroxytryptamine, 6, agonist, 5-HT6, agonists, Receptors, 3904, Tocris Bioscience
1 Citation for WAY 208466 dihydrochloride
Citations are publications that use Tocris products. Selected citations for WAY 208466 dihydrochloride include:
Sun et al (2018) Activation and blockade of basolateral amygdala 5-HT6 receptor produce anxiolytic-like behaviors in an experimental model of Parkinson's disease. Neuropharmacology 137 275 PMID: 29778944
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.