Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewWWL 113
Description: Ces3 and Ces1f inhibitor
Chemical Name: 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Biological Activity for WWL 113
WWL 113 is a carboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.
Technical Data for WWL 113
| M. Wt | 466.53 |
| Formula | C29H26N2O4 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 947669-86-5 |
| PubChem ID | 17759482 |
| InChI Key | AKIIPHDGVCFVCC-UHFFFAOYSA-N |
| Smiles | CN(C(OC3=CC=C(C4=CC=C(C(OCC)=O)C=C4)C=C3)=O)CC1=CC=CC(C2=CC=NC=C2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for WWL 113
References for WWL 113
References are publications that support the biological activity of the product.
Dominguez et al (2014) Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat.Chem.Biol. 10 113 PMID: 24362705
View Related Products by Target
View Related Products by Product Action
Keywords: WWL 113, WWL 113 supplier, WWL113, carboxyesterases, Ces3, ces1d, cesif, ABHD6, hydrolases, serine, lipids, metabolism, obesity, diabetes, Other, Hydrolases, Lipid, Metabolism, 5259, Tocris Bioscience
1 Citation for WWL 113
Citations are publications that use Tocris products. Selected citations for WWL 113 include:
Patra et al (2018) Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol 20 811 PMID: 29941929
Reviews for WWL 113
There are currently no reviews for this product. Be the first to review WWL 113 and earn rewards!
Have you used WWL 113?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image