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Submit ReviewWZ 811
Description: Potent CXCR4 antagonist
Chemical Name: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
Purity: ≥99% (HPLC)
Biological Activity for WZ 811
WZ 811 is a potent chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM).
Technical Data for WZ 811
| M. Wt | 290.36 |
| Formula | C18H18N4 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 55778-02-4 |
| PubChem ID | 11565518 |
| InChI Key | KBVFRXIGQQRMEF-UHFFFAOYSA-N |
| Smiles | C1(CNC3=NC=CC=C3)=CC=C(CNC2=NC=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for WZ 811
References for WZ 811
References are publications that support the biological activity of the product.
Zhan et al (2007) Discovery of small molecule CXCR4 antagonists. J.Med.Chem. 50 5655 PMID: 17958344
Reyes et al (2002) Pyridinium N-(2'-azinyl)aminides: regioselective synthesis of N-(2-pyridyl) substituted polyamines. Chem.Inform. 34
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Keywords: WZ 811, WZ 811 supplier, WZ811, chemokine, receptors, receptor, type, 4, antagonists, CXCR4, Chemokine, CXC, Receptors, 3951, Tocris Bioscience
Citations for WZ 811
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Currently there are no citations for WZ 811.
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