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Submit ReviewXEN 445
Description: Selective endothelial lipase inhibitor; orally bioavailable
Chemical Name: 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for XEN 445
XEN 445 is a selective endothelial lipase (EL) inhibitor (IC50 = 237 nM for human EL). Exhibits >20-fold selectivity for EL over lipoprotein lipase (LPL) and hepatic lipase (HL). Increases high density lipoprotein cholesterol (HDLc) plasma levels in mice. Orally bioavailable.
Technical Data for XEN 445
| M. Wt | 366.33 |
| Formula | C18H17F3N2O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1515856-92-4 |
| PubChem ID | 72736173 |
| InChI Key | NBGRERFNOKZQLO-AWEZNQCLSA-N |
| Smiles | OC(C1=C(N2CC[C@H](OCC3=CC=CC=N3)C2)C=CC(C(F)(F)F)=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for XEN 445
References for XEN 445
References are publications that support the biological activity of the product.
Sun et al (2013) Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg.Med.Chem. 21 7724 PMID: 24211162
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Keywords: XEN 445, XEN 445 supplier, XEN445, Selective, endothelial, lipase, EL, inhibitors, inhibits, orally, bioavailable, Lipases, 5839, Tocris Bioscience
Citations for XEN 445
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Currently there are no citations for XEN 445.
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