Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewY 134
Description: Selective estrogen receptor modulator (SERM), selective for ERα
Chemical Name: [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]methanone
Purity: ≥98% (HPLC)
Biological Activity for Y 134
Y 134 is a selective estrogen receptor modulator (SERM) that displays selectivity for ERα over ERβ (Ki values are 0.09 and 11.31 nM respectively) and no cross-reactivity with mineralocorticoid, glucocorticoid, androgen and progesterone receptors. Acts as an agonist in the bone and antagonist in reproductive tissue. Suppresses estrogen-stimulated proliferation of ER-positive human breast cancer MCF-7 and T47D cells.
Technical Data for Y 134
| M. Wt | 472.6 |
| Formula | C28H28N2O3S |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 849662-80-2 |
| PubChem ID | 11784736 |
| InChI Key | LQEOPHGPHCWOAC-UHFFFAOYSA-N |
| Smiles | CC(C)N1CCN(CC1)C1=CC=C(C=C1)C(=O)C1=C(SC2=CC(O)=CC=C12)C1=CC=C(O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Y 134
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.26 | 100 | |
| ethanol | 47.26 | 100 |
Preparing Stock Solutions for Y 134
The following data is based on the product molecular weight 472.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.12 mL | 10.58 mL | 21.16 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.23 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Y 134
References for Y 134
References are publications that support the biological activity of the product.
Yang et al (2005) Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor α and their bioactivities in vivo. Bioorg.Med.Chem.Lett. 15 1505 PMID: 15713417
Ning et al (2007) Biological activities of a novel selective oestrogen receptor modulator derived from ralox. (Y134). Br.J.Pharmacol. 150 19 PMID: 17115070
If you know of a relevant reference for Y 134, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Y 134, Y 134 supplier, Selective, estrogen, receptor, modulators, SERM, selective, Erα, Eralpha, ERR, Estrogen, Receptors, Y134, and, Related, 2676, Tocris Bioscience
Citations for Y 134
Citations are publications that use Tocris products.
Currently there are no citations for Y 134. Do you know of a great paper that uses Y 134 from Tocris? Please let us know.
Reviews for Y 134
There are currently no reviews for this product. Be the first to review Y 134 and earn rewards!
Have you used Y 134?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Pathways for Y 134
