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Description: Notch signaling pathway activator; enhances the self-renewal capability of NSCs; active in vivo
Chemical Name: 5-(3-Methoxyphenoxy)-N2-[4-(1-methylethyl)phenyl]-2,4-quinazolinediamine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Yhhu 3792
Yhhu 3792 is a notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo. Promotes the expression of Notch target genes, Hes3 and Hes5. Expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) after chronic administration in mice. Increases the spatial and episodic memory in mice.
Compound Libraries for Yhhu 3792
Yhhu 3792 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for Yhhu 3792
| M. Wt | 436.93 |
| Formula | C24H24N4O2.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2624336-93-0 |
| InChI Key | WNNJMAWCEOKXEJ-UHFFFAOYSA-N |
| Smiles | COC1=CC=CC(OC2=CC=CC3=C2C(N)=NC(NC4=CC=C(C(C)C)C=C4)=N3)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Yhhu 3792
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.69 | 100 |
Preparing Stock Solutions for Yhhu 3792
The following data is based on the product molecular weight 436.93. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.29 mL | 11.44 mL | 22.89 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.29 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets for Yhhu 3792
References for Yhhu 3792
References are publications that support the biological activity of the product.
Lu (2018) A novel 2-phenylamino-quinazoline-based compound expands the neural stem cell pool and promotes the hippocampal neurogenesis and the cognitive ability of adult mice. Stem Cells 36 1273 PMID: 29726088
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Keywords: Yhhu 3792, Yhhu 3792 supplier, Yhhu3792, Notch, signaling, pathway, activators, activates, neural, stem, cells, NSCs, memory, in, vivo, Other, Signaling, Stem, Cell, Proliferation, 6599, Tocris Bioscience
1 Citation for Yhhu 3792
Citations are publications that use Tocris products. Selected citations for Yhhu 3792 include:
Srustidhar et al (2022) Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine. Mucosal Immunol 15 940-951 PMID: 35840681
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