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Submit ReviewYM 230888
Discontinued Product
2986 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
Description: Selective mGlu1 antagonist
Chemical Name: 4-(Cycloheptylamino)-N-[[(2R)-tetrahydro-2-furanyl]methyl]-thieno[2,3-d]pyrimidine-6-methanamine
Purity: ≥99% (HPLC)
Biological Activity for YM 230888
Selective mGlu1 antagonist (Ki = 13 nM). Inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells (IC50 = 13 nM). Displays antinociceptive and analgesic effects in vitro; exhibits no significant sedative effect on locomotor activity.
Licensing Information
Sold with the permission of Astellas Pharma Inc.
Technical Data for YM 230888
| M. Wt | 360.52 |
| Formula | C19H28N4OS |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 446257-23-4 |
| PubChem ID | 11682007 |
| InChI Key | SASNRPJKZVJWQW-OAHLLOKOSA-N |
| Smiles | C1(NC4CCCCCC4)=C(C=C(CNC[C@H]3CCCO3)S2)C2=NC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for YM 230888
References for YM 230888
References are publications that support the biological activity of the product.
Kohara et al (2007) Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models. Eur.J.Pharmacol. 571 8 PMID: 17597604
Satow et al (2008) Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents: detailed investigations with a selective allost J.Pharmacol.Exp.Ther. 326 577 PMID: 18487514
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Keywords: YM 230888, YM 230888 supplier, YM230888, mGlu1, metabotropic, glutamate, receptors, group, I, 1, antagonist, antagonists, mGlu, selective, Glutamate, (Metabotropic), Group, Receptors, 2986, Tocris Bioscience
Citations for YM 230888
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Currently there are no citations for YM 230888.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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Parkinson's Disease Poster
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