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Submit ReviewYM 26734
Description: Secretory phospholipase A2 (sPLA2) inhibitor
Chemical Name: 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone
Purity: ≥95% (HPLC)
Biological Activity for YM 26734
YM 26734 is a competitive inhibitor of secretory phospholipase A2 (sPLA2) that exhibits a broad inhibitory profile to several sPLA2s (IC50 values are 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.
Technical Data for YM 26734
| M. Wt | 730.97 |
| Formula | C45H62O8 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 144337-18-8 |
| PubChem ID | 9853400 |
| InChI Key | CEJAYJCUSZHYDS-UHFFFAOYSA-N |
| Smiles | OC1=C(C2CC(C4=CC=C(O)C=C4)OC3=C2C=CC(O)=C3)C(O)=C(C(CCCCCCCCCCC)=O)C(O)=C1C(CCCCCCCCCCC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for YM 26734
References for YM 26734
References are publications that support the biological activity of the product.
Miyake et al (1993) Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carregeenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2. Br.J.Pharmacol. 110 447 PMID: 8220906
Miyake et al (1994) Exogenous group II phospholipase A2 prostaglandin E2 production in mouse peritoneal macrophages. Eur.J.Pharmacol. 253 155 PMID: 8013541
Hamaguchi et al (2003) Induction of distinct sets of secretory phospholipase A2 in rodents during inflammation. Biochim.Biophys.Acta 1635 37 PMID: 14642775
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Keywords: YM 26734, YM 26734 supplier, Secretory, phospholipases, A2, sPLA2, inhibitors, inhibits, Esterases, YM26734, Phospholipases, 2522, Tocris Bioscience
2 Citations for YM 26734
Citations are publications that use Tocris products. Selected citations for YM 26734 include:
Bianca et al (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Front Mol Neurosci 161 1835 PMID: 20825409
Pernet et al (2014) Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat Commun 5 5105 PMID: 25290234
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