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Submit ReviewYohimbine hydrochloride
Description: Selective α2 antagonist
Chemical Name: 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Yohimbine hydrochloride
Yohimbine hydrochloride is a α2-adrenoceptor antagonist (pKi values are 8.52, 8.00 and 9.17 for human α2A, α2B and α2C receptors respectively).
Diastereomer also available.
Technical Data for Yohimbine hydrochloride
| M. Wt | 390.91 |
| Formula | C21H26N2O3.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 65-19-0 |
| PubChem ID | 6169 |
| InChI Key | PIPZGJSEDRMUAW-VJDCAHTMSA-N |
| Smiles | [H][C@]12C4=C(C(C=CC=C5)=C5N4)CCN1C[C@@]3([H])[C@]([C@@H]([C@@](OC)=O)[C@@H](O)CC3)([H])C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Yohimbine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.82 | 20 with gentle warming |
Preparing Stock Solutions for Yohimbine hydrochloride
The following data is based on the product molecular weight 390.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.79 mL | 63.95 mL | 127.91 mL |
| 1 mM | 2.56 mL | 12.79 mL | 25.58 mL |
| 2 mM | 1.28 mL | 6.4 mL | 12.79 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
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Product Datasheets for Yohimbine hydrochloride
References for Yohimbine hydrochloride
References are publications that support the biological activity of the product.
Doxey et al (1984) Comparison of the α-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine. Naunyn Schmiedebergs Arch.Pharmacol. 325 136 PMID: 6144048
Lalchandani et al (2002) Yohimbine dimers exhibiting selectivity for the human α2c-adrenoceptor subtype. J.Pharmacol.Exp.Ther. 303 979 PMID: 12438517
Redfern and Williams (1995) A re-evaluation of the role of α2-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat. Br.J.Pharmacol. 116 2081 PMID: 8640349
Goldberg and Robertson (1987) Yohimbine: a pharmacological probe for study of the α2-adrenoceptor. Pharmacol.Rev. 35 143
If you know of a relevant reference for Yohimbine hydrochloride, please let us know.
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Keywords: Yohimbine hydrochloride, Yohimbine hydrochloride supplier, Selective, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, antagonist, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Receptors, Adrenergic, Alpha-2, 1127, Tocris Bioscience
21 Citations for Yohimbine hydrochloride
Citations are publications that use Tocris products. Selected citations for Yohimbine hydrochloride include:
Hirschberg et al (2017) Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. Elife 6 PMID: 29027903
Barnea et al (2008) The genetic design of signaling cascades to record receptor activation. Proc Natl Acad Sci U S A 105 64 PMID: 18165312
Corcoran et al (2014) Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. Mol Metab 34 51 PMID: 24381267
Mondal et al (2013) Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons. PLoS One 8 e60365 PMID: 23565235
Ryan et al (2013) Relaxin-3/RXFP3 system regulates alcohol-seeking. Proc Natl Acad Sci U S A 110 20789 PMID: 24297931
Gozzi et al (2013) Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine. Neuropsychopharmacology 38 2120 PMID: 23736277
Soty et al (2015) A gut-brain neural circuit controlled by intestinal gluconeogenesis is crucial in metabolic health. Psychopharmacology (Berl) 4 106 PMID: 25685698
Phelps et al (2015) Psychopharmacological characterisation of the successive negative contrast effect in rats. Proc Natl Acad Sci U S A 232 2697 PMID: 25791190
Yuen et al (2014) Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons. J Biol Chem 289 25177 PMID: 25056951
Kastman et al (2016) Nucleus incertus Orexin2 receptors mediate alcohol seeking in rats Neuropharmacology 110 82 PMID: 27395787
Delaney and Crane (2016) Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep 6 19255 PMID: 26755335
Gazarini et al (2015) PTSD-like memory generated through enhanced noradrenergic activity is mitigated by a dual step pharmacological intervention targeting its reconsolidation. Int J Neuropsychopharmacol 18 PMID: 25539509
Dudek et al (2015) A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands guanf. and Yohimbine in Rats with Diet-Induced Obesity. PLoS One 10 e0141327 PMID: 26506439
Scardochio et al (2015) The Effects of Electrical and Optical Stimulation of Midbrain DArgic Neurons on Rat 50-kHz Ultrasonic Vocalizations. Front Behav Neurosci 9 331 PMID: 26696851
Costello et al (2014) Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats. Neuropsychopharmacology 39 1843 PMID: 24513971
Ciccocioppo et al (2014) Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat. Neuropsychopharmacology 39 2601 PMID: 24863033
Drake et al (2014) The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input. J Physiol 592 3611 PMID: 24879873
Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110 PMID: 21315691
André et al (2006) Enhancing functional production of G protein-coupled receptors in Pichia pastoris to levels required for structural studies via a single expression screen. Protein Sci 15 1115 PMID: 16597836
Maupoil et al (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol 150 899 PMID: 17325650
Marchese et al (2003) Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications. Br J Pharmacol 140 520 PMID: 12970091
Do you know of a great paper that uses Yohimbine hydrochloride from Tocris? Please let us know.
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Chronic yohimbine stress increases vulnerability to reinstatement of palatable food seeking.
By
Kevin Ball on 01/25/2019
Assay Type: In Vivo
Species: Rat
To model chronic stress, rats were injected daily with yohimbine (0.0, 2.5, or 5.0 mg/kg; i.p.) during the first 7 days of extinction from palatable food self-administration. Injections were combined with SCH-23390 (0.0, 5.0, or 10.0 μg/kg; i.p.), a dopamine D1-like receptor antagonist. Rats were then tested for reinstatement of food seeking triggered by acute yohimbine (0.0, 1.0, or 2.0 mg/kg; i.p.) and pellet priming. Rats treated previously with chronic yohimbine displayed increased responding following acute yohimbine and pellet priming relative to non-chronically stressed rats under certain conditions. SCH-23390 combined with repeated yohimbine injections attenuated these effects.
Literature in this Area
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