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Submit ReviewZD 2079
Discontinued Product
2154 has been discontinued.
View all Adrenergic β<sub>3</sub> Receptors products.
Description: β3-adrenoceptor agonist
Chemical Name: 4-[2-[[(2R)-2-Hydroxy-2-phenylethyl]amino]ethoxy]-benzeneacetic acid hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for ZD 2079
ZD 2079 is an β3-adrenoceptor agonist. Relaxes rat mesenteric artery and isolated aorta in vitro. Inhibits ob gene expression and circulating leptin levels in lean mice in vivo.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for ZD 2079
| M. Wt | 351.83 |
| Formula | C18H21NO4.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 178600-17-4 |
| PubChem ID | 158793 |
| InChI Key | KCEFVYIWOQSJCH-LMOVPXPDSA-N |
| Smiles | Cl[H].O[C@@H](CNCCOC1=CC=C(CC(O)=O)C=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ZD 2079
References for ZD 2079
References are publications that support the biological activity of the product.
Brawley et al (2000) Role of endothelium/nitric oxide in atypical β-adrenoceptor-mediated relaxation in rat isolated aorta. Eur.J.Pharmacol. 398 285 PMID: 10854841
Kozlowska et al (2003) Atypical β-adrenoceptors, different from β3-adrenoceptors, relax the rat isolated mesenteric artery. Br.J.Pharmacol. 140 3 PMID: 12967929
Trayhurn et al (1996) Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the β3-adrenoceptor agonists BRL 35135A and ZD2079. Biochem.Biophys.Res.Comm. 228 605
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Keywords: ZD 2079, ZD 2079 supplier, β3-adrenoceptor, b3-adrenoceptor, β3-adrenergic, b3-adrenergic, agonists, Receptors, ZD2079, AstraZeneca, Adrenergic, Beta-3, 2154, Tocris Bioscience
1 Citation for ZD 2079
Citations are publications that use Tocris products. Selected citations for ZD 2079 include:
Suárez et al (2014) Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech 7 129 PMID: 24159189
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.