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Submit ReviewZD 9379
Description: Brain penetrant NMDA antagonist; acts at glycine site
Chemical Name: 7-Chloro-2,3-dihydro-2-(4-methoxy-2-methylphenyl)pyridazino [4,5-b] quinoline-1,4,10(5H)trione
Purity: ≥98% (HPLC)
Biological Activity for ZD 9379
ZD 9379 is a NMDA receptor antagonist; acts at glycine site. Neuroprotective; reduces infarct size and frequency of spreading depressions in a rat model of ischemic stroke. Brain penetrant.
Licensing Information
Sold for research purposes under agreement from AstraZeneca
Technical Data for ZD 9379
| M. Wt | 383.79 |
| Formula | C19H14ClN3O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 170142-20-8 |
| PubChem ID | 9843028 |
| InChI Key | PSTDMIAVUUYOOQ-UHFFFAOYSA-N |
| Smiles | O=C2C3=C(C(NN(C4=C(C)C=C(OC)C=C4)C3=O)=O)NC1=CC(Cl)=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ZD 9379
References for ZD 9379
References are publications that support the biological activity of the product.
Bare (1993) Pyridazino[4,5-b]quinolinediones: a series of novel glycine site NMDA antagonists with potent in vitro and in vivo properties. Abstracts of Papers of the ACS 205 79. Abstract.
Takano (1997) Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies. Stroke. 28 1255 PMID: 9183359
Tatlisumak (2000) A glycine antagonist ZD9379 reduces number of spreading depressions and infarct size in rats with permanent middle cerebral artery occlusion. Acta.Neurochir.Suppl. 76 331 PMID: 11450037
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Keywords: ZD 9379, ZD 9379 supplier, ZD9379, glycine, antagonists, NMDA, neuroprotectives, brain, penetrant, Receptors, 3322, Tocris Bioscience
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