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ZE 132

Cat. No. 7533 Submit a Review Datasheet / COA / SDS
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Description: Potent and selective PD-1/PD-L1 interaction inhibitor
Chemical Name: 2-[[[5-Chloro-2-[(5-cyano-3-pyridinyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl][3-(dimethylamino)propyl]amino]ethanesulfonic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ZE 132

ZE 132 binds to programmed cell death-ligand 1 (PD-L1) with high affinity (KD = 19.36 nM); it potently and selectively inhibits the interaction between programmed cell death-1 (PD-1) and PD-L1 (IC50 = 23.49 nM). ZE 132 promotes CD8+ T cell activation and improves the in vitro cytotoxic killing activity of T-cells. ZE 132 treatment can increase Cxcl9 mRNA expression and lower Tgfb1 mRNA expression in CT26 mouse colorectal cancer model. ZE 132 shows antitumor effects, inhibiting growth of CT26 tumors in mice by 64%.

Technical Data for ZE 132

M. Wt 721.27
Formula C37H41ClN4O7S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2566710-63-0
PubChem ID 155367962
InChI Key QJSJWFVBDAPNAE-UHFFFAOYSA-N
Smiles CN(CCCN(CC1=C(C=C(C(Cl)=C1)OCC2=CC=CC(C3=CC=C4OCCOC4=C3)=C2C)OCC5=CN=CC(C#N)=C5)CCS(O)(=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ZE 132

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 72.13 100

Preparing Stock Solutions for ZE 132

The following data is based on the product molecular weight 721.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.39 mL 6.93 mL 13.86 mL
5 mM 0.28 mL 1.39 mL 2.77 mL
10 mM 0.14 mL 0.69 mL 1.39 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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References for ZE 132

References are publications that support the biological activity of the product.

Liu et al (2021) Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy. Br.J.Pharmacol. 178 2651 PMID: 33768523

If you know of a relevant reference for ZE 132, please let us know.

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Citations for ZE 132

Citations are publications that use Tocris products.

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Literature in this Area

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