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ZK 164015

Cat. No. 2183 Submit a Review Datasheet / COA / SDS

Discontinued Product

2183 has been discontinued.

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Description: Potent estrogen receptor antagonist
Chemical Name: 2-(4-Hydroxyphenyl)-3-methyl-1-[10-(pentylsulfonyl)decyl]-1H-indol-5-ol
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for ZK 164015

ZK 164015 is a potent estrogen receptor silent antagonist. Inhibits 17β-estradiol stimulation of luciferase activity (IC50 = 0.025 μM); potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro (IC50 ~ 1 nM).

Technical Data for ZK 164015

M. Wt 513.73
Formula C30H43NO4S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 177583-70-9
PubChem ID 9806489
InChI Key LYJSJVYJLZOMCD-UHFFFAOYSA-N
Smiles CCCCCS(=O)(=O)CCCCCCCCCCN1C2=CC=C(O)C=C2C(C)=C1C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ZK 164015

References are publications that support the biological activity of the product.

Liu et al (1999) The anti-estrogen hydroxytamoxifen is a potent antagonist in a novel yeast system. Biol.Chem. 380 1341 PMID: 10614829

Walter et al (2004) Synthesis and biological evaluation of stilbene-based pure estrogen antagonists. Bioorg.Med.Chem.Lett. 14 4659 PMID: 15324884

Biberger and von Angerer (1996) 2-Phenylindoles with sulfur containing side chains. Estrogen receptor affinity, antiestrogenic potency, and antitumour activity. J.Steroid Biochem.Molec.Biol. 58 31

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Citations for ZK 164015

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Pathways for ZK 164015

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.