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Submit ReviewZK 93423 hydrochloride
Description: Potent benzodiazepine agonist
Chemical Name: 4-(Methoxymethyl)-6-(phenylmethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for ZK 93423 hydrochloride
ZK 93423 hydrochloride is a potent benzodiazepine receptor agonist (IC50 = 1 nM). Non-selective between α1-, α2-, α3- and α5-subunit containing GABAA receptors (Ki values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [3H]Ro15-1788 binding to human recombinant α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2 receptors respectively). Anxiolytic following systemic administration in vivo.
Technical Data for ZK 93423 hydrochloride
| M. Wt | 426.9 |
| Formula | C23H22N2O4.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1216574-52-5 |
| PubChem ID | 56972166 |
| InChI Key | KHMDBPAODAAMBQ-UHFFFAOYSA-N |
| Smiles | Cl.CCOC(=O)C1=C(COC)C2=C(NC3=C2C=C(OCC2=CC=CC=C2)C=C3)C=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ZK 93423 hydrochloride
References for ZK 93423 hydrochloride
References are publications that support the biological activity of the product.
Stephens et al (1984) Discriminative stimulus properties of β-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors. Psychopharmacology 83 233 PMID: 6089245
File and Baldwin (1987) Effects of β-carbolines in animal models of anxiety. Brain Res.Bull. 19 293 PMID: 3315125
Cox et al (1998) Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (ZK 934 J.Med.Chem. 41 2537 PMID: 9651158
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Keywords: ZK 93423 hydrochloride, ZK 93423 hydrochloride supplier, Potent, benzodiazepine, agonists, GABAA, Receptors, ZK93423, hydrochloride, 1994, Tocris Bioscience
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Literature in this Area
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