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Submit ReviewZK 93426 hydrochloride
Description: Potent and competitive benzodiazepine antagonist
Chemical Name: 4-Methyl-5-(1-methylethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for ZK 93426 hydrochloride
ZK 93426 hydrochloride is a potent, selective and competitive benzodiazepine receptor antagonist (IC50 values are 0.4 and 0.7 nM for inhibition of [3H]-flunitrazepam binding to rat cerebellum and hippocampus respectively). Similar in vivo profile to flumazenil (Ro 15-1788, Cat No. 1328); produces anxiogenic effects in some behavioral tests and anxiolytic effects in others. Orally active.
Technical Data for ZK 93426 hydrochloride
| M. Wt | 348.82 |
| Formula | C18H20N2O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1216792-30-1 |
| PubChem ID | 56972167 |
| InChI Key | RNQJDOYVHCISJU-UHFFFAOYSA-N |
| Smiles | Cl.CCOC(=O)C1=C(C)C2=C(NC3=C2C(OC(C)C)=CC=C3)C=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ZK 93426 hydrochloride
References for ZK 93426 hydrochloride
References are publications that support the biological activity of the product.
Jensen et al (1984) Evaluation of the β-carboline ZK 93 426 as a benzodiazepine receptor antagonist. Psychopharmacology 83 249 PMID: 6089247
Corda et al (1987) Enhancement of γ-aminobutyric acid binding by the anxiolytic β-carbolines ZK 93423 and ZK 91296. J.Neurochem. 48 1355 PMID: 2881979
File and Baldwin (1987) Effects of β-carbolines in animal models of anxiety. Brain Res.Bull. 19 293 PMID: 3315125
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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