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Submit ReviewZopiclone
Description: Benzodiazepine agonist
Chemical Name: 4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b] pyrazin-5-yl ester
Purity: ≥99% (HPLC)
Biological Activity for Zopiclone
A non benzodiazepine BZR agonist, with little difference in affinity for the BZ1 and BZ2 subtypes; however its CNS effects differ from those of other BZR ligands and this may be due to interaction with a different subunit.
Technical Data for Zopiclone
| M. Wt | 388.81 |
| Formula | C17H17ClN6O3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 43200-80-2 |
| PubChem ID | 5735 |
| InChI Key | GBBSUAFBMRNDJC-UHFFFAOYSA-N |
| Smiles | CN1CCN(CC1)C(=O)OC1N(C(=O)C2=NC=CN=C12)C1=CC=C(Cl)C=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Zopiclone
References for Zopiclone
References are publications that support the biological activity of the product.
Goa and Heel (1986) ZopiC.. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy as a hypnotic. Drugs 32 48 PMID: 2874974
Im et al (1993) Potentiation of γ-aminobutyric acid induced chloride currents by various benzodiazepine site agonists with the α1γ2, β2γ2 and α1β2γ2 subtypes of cloned γ-aminobutyric acid type A receptors. Mol.Pharmacol. 44 866 PMID: 7901754
Munakata et al (1996) Heterogeneous distribution of benzodiazepine receptors among rat neostriatal neurones. Br.J.Pharmacol. 118 820 PMID: 8762113
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Keywords: Zopiclone, Zopiclone supplier, Benzodiazepine, agonists, GABAA, Receptors, 1094, Tocris Bioscience
1 Citation for Zopiclone
Citations are publications that use Tocris products. Selected citations for Zopiclone include:
Petroski et al (2006) Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 subunit-containing GABAA receptors. J Pharmacol Exp Ther 317 369 PMID: 16399882
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.