Amiodarone hydrochloride

Name: Amiodarone hydrochloride
Brand: Tocris Bioscience
SKU: 4095

Cat. No. 4095 3 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

4095 has been discontinued.

View all Other Channel Modulators products.

Description: Broad spectrum ion channel blocker; antiarrhythmic

Chemical Name: 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride

Purity: ≥99% (HPLC)

Datasheet

Citations (3)

Reviews

Biological Activity Technical Data Datasheets References

Biological Activity for Amiodarone hydrochloride

Amiodarone hydrochloride is a broad-spectrum ion channel blocker; blocks late I_Na, I_Ca, I_Kr and I_Ks and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca²⁺ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations. Amiodarone depolarizes the resting membrane potential of the triple-negative breast cancer (TNBC) cells and decreases cell migration.

Technical Data for Amiodarone hydrochloride

M. Wt	681.77
Formula	C₂₅H₂₉I₂NO₃.HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	19774-82-4
PubChem ID	29770
InChI Key	ITPDYQOUSLNIHG-UHFFFAOYSA-N
Smiles	CCCCC2=C(C(C3=CC(I)=C(OCCN(CC)CC)C(I)=C3)=O)C1=CC=CC=C1O2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Amiodarone hydrochloride

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Amiodarone hydrochloride

References are publications that support the biological activity of the product.

Antzelevitch et al (2004) Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110 904 PMID: 15302796

di Matola et al (2000) Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism. J.Clin.Endocrin.Metab. 85 4323 PMID: 11095475

Balgi et al (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4 e7124 PMID: 19771169

Han et al (2009) Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not DA neurons. PLoS One. 4 7155 PMID: 19774075

Payne et al (2021) Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer. EBioMedicine 75 103767 PMID: 34933180

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⚠ WARNING: This product can expose you to chemicals including Amiodarone hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov