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Submit ReviewAmitriptyline hydrochloride
Description: 5-HT and NA reuptake inhibitor (SNRI); also TrkA/B agonist
Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Amitriptyline hydrochloride
Amitriptyline hydrochloride is an inhibitor of serotonin and noradrenaline uptake; also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA). Also a TrkA/B agonist. Induces neurite outgrowth in PC12 cells.
Technical Data for Amitriptyline hydrochloride
| M. Wt | 313.86 |
| Formula | C20H23N.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 549-18-8 |
| PubChem ID | 11065 |
| InChI Key | KFYRPLNVJVHZGT-UHFFFAOYSA-N |
| Smiles | CN(CC\C=C2/C3=C(C=CC=C3)CCC1=CC=CC=C12)C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Amitriptyline hydrochloride
References for Amitriptyline hydrochloride
References are publications that support the biological activity of the product.
Merck Index 12 85
Sanchez and Hyttel (1999) Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell.Mol.Neurobiol. 19 467 PMID: 10379421
Ghelardini et al (2000) Antinociception induced by amitript. and imipr. is mediated by α2A-adrenoceptors. Jpn.J.Pharmacol. 82 130 PMID: 10877531
Sawynok et al (2001) Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J.Psychiatry Neurosci. 26 21 PMID: 11212590
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1 Citation for Amitriptyline hydrochloride
Citations are publications that use Tocris products. Selected citations for Amitriptyline hydrochloride include:
Vladislav et al (2022) Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (Kir 4.1/Kir 5.1) in the cortical collecting duct. Br J Pharmacol 179 2953-2968 PMID: 34904226
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.