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Description: Potent and selective 5-HT6 antagonist
Chemical Name: N-(1-(5-Chloro-2,3-dimethoxyphenyl)ethyl)-2-(methylsulfonyl)-5-(piperazin-1-yl)aniline hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for PRX 07034
PRX 07034 is a potent and selective 5-HT6 receptor antagonist (IC50 = 19 nM, Ki = 4 - 8 nM). Enhances working memory in rats.
Compound Libraries for PRX 07034
PRX 07034 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for PRX 07034
| M. Wt | 490.44 |
| Formula | C21H28ClN3O4S.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 903580-39-2 |
| PubChem ID | 23653584 |
| InChI Key | PILCQJJJAFRKHO-UHFFFAOYSA-N |
| Smiles | ClC1=CC(C(NC2=C(S(C)(=O)=O)C=CC(N3CCNCC3)=C2)C)=C(OC)C(OC)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PRX 07034
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.81 | 20 with gentle warming | |
| DMSO | 49.04 | 100 |
Preparing Stock Solutions for PRX 07034
The following data is based on the product molecular weight 490.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.04 mL | 10.19 mL | 20.39 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.04 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
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Product Datasheets for PRX 07034
References for PRX 07034
References are publications that support the biological activity of the product.
Mohler et al (2012) The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 220 687 PMID: 21989804
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Keywords: PRX 07034, PRX 07034 supplier, PRX07034, potent, selective, serotonergic, 5HT6, receptor, 5-HT, antagonists, antagonism, 5-HT6, Receptors, 6748, Tocris Bioscience
Citations for PRX 07034
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.