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Submit ReviewDiphenhydramine hydrochloride
Description: H1 antagonist
Alternative Names: DPH
Chemical Name: 2-Diphenylmethoxy-N,N-dimethylethanamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Diphenhydramine hydrochloride
Diphenhydramine hydrochloride is a H1 receptor antagonist. Antihistamine.
Technical Data for Diphenhydramine hydrochloride
| M. Wt | 291.82 |
| Formula | C17H21NO.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 147-24-0 |
| PubChem ID | 8980 |
| InChI Key | PCHPORCSPXIHLZ-UHFFFAOYSA-N |
| Smiles | CN(CCOC(C2=CC=CC=C2)C1=CC=CC=C1)C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Diphenhydramine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 29.18 | 100 |
Preparing Stock Solutions for Diphenhydramine hydrochloride
The following data is based on the product molecular weight 291.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.43 mL | 17.13 mL | 34.27 mL |
| 5 mM | 0.69 mL | 3.43 mL | 6.85 mL |
| 10 mM | 0.34 mL | 1.71 mL | 3.43 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
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Product Datasheets for Diphenhydramine hydrochloride
References for Diphenhydramine hydrochloride
References are publications that support the biological activity of the product.
Khalia et al (1999) Block of potassium currents in guinea pig ventricular myocytes and lengthening of cardiac repolarization in man by the histamine H1 receptor antagonist diphenhydramide. J.Pharmacol.Exp.Ther. 288 858 PMID: 9918600
If you know of a relevant reference for Diphenhydramine hydrochloride, please let us know.
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Keywords: Diphenhydramine hydrochloride, Diphenhydramine hydrochloride supplier, H1, receptor, antagonists, Receptors, Histamine, histaminergic, DPH, 3072, Tocris Bioscience
Citations for Diphenhydramine hydrochloride
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Currently there are no citations for Diphenhydramine hydrochloride. Do you know of a great paper that uses Diphenhydramine hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.