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Submit ReviewDaminozide
Description: Selective KDM2/7 inhibitor
Chemical Name: 1-(2,2-Dimethylhydrazide)butanedioic acid
Biological Activity for Daminozide
Daminozide is a histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC50 > 100 μM).
Technical Data for Daminozide
| M. Wt | 160.17 |
| Formula | C6H12N2O3 |
| Storage | Store at RT |
| CAS Number | 1596-84-5 |
| PubChem ID | 15331 |
| InChI Key | NOQGZXFMHARMLW-UHFFFAOYSA-N |
| Smiles | O=C(NN(C)C)CCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Daminozide
References for Daminozide
References are publications that support the biological activity of the product.
Rose et al (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J.Med.Chem. 55 6639 PMID: 22724510
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Keywords: Daminozide, Daminozide supplier, jmjc, kdm2/7, kdm2a, kdm7a, phf8, histone, demethylases, inhibits, inhibitors, selective, epigenetics, Histone, Demethylases, 4684, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Daminozide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
Citations for Daminozide
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Currently there are no citations for Daminozide.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.