"pharmacology" has 1 results in Products.
Lestaurtinib
"pharmacology" has 4 results in Targets.
Chemogenetics
Chemogenetics is a powerful and specific method to control and investigate intracellular signaling pathways. Most widely used in neuroscience to control neuronal or glial cell activity, chemogenetic experiments employ compounds that selectively target a genetically-modified G protein-coupled receptor (GPCR; DREADD) or a chimeric ion channel (PSAM).
More InfoPSEMs
Pharmacologically Selective Effector Molecules (PSEMs) are inert ligands, specific for genetically-modified, chimeric ion channels, termed Pharmacologically Selective Actuator Modules (PSAMs). PSAMs containing the 5-HT3 ion pore domain allow activation of neuronal activity, while GlyR and GABAc containing chimeras are inhibitory
More InfoPharmacology
Pharmacology is the study of interactions between drugs and biological systems. It is also the study of drug sources and their intrinsic properties. Most drugs act on defined pharmacological targets in order to exert their effects. The term drug is intended to mean any substance that alters normal biochemical function. Drugs with medicinal properties are termed pharmaceuticals.
Tocris products are categorised according to pharmacological activity. Click on any link below for further information.
More Info"pharmacology" has 4 results in Resources.
Allosteric GPCR Pharmacology Poster
G protein-coupled receptors (GPCRs) are intrinsically allosteric proteins. This poster provides insights into allosteric mechanisms of GPCR biology, highlighting key facets of GPCR allostery and therapeutic applications of allosteric modulators.
More InfoBrowse the Tocris Product Range by Pharmacological Activity
View and buy high purity products active at a range of pharmacological targets from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents.
More InfoChemogenetics Research Bulletin
Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.
More InfoGPCR Efficacy and Biased Agonism Life Science Poster
GPCRs can interact with multiple distinct transducers or regulatory proteins and these can be preferentially engaged in an agonist-specific manner giving rise to biased agonism. This poster discusses cutting edge GPCR signaling pharmacology and highlights therapeutic applications of biased agonism.
More Info