Hsp90
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).
Hsp90 Inhibitors |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1515 | 17-AAG |
| Selective Hsp90 inhibitor | |
| 2435 | CCT 018159 |
| Hsp90 inhibitor | |
| 4701 | EC 144 |
| High affinity, potent and selective Hsp90 inhibitor | |
| 3387 | Gedunin |
| Hsp90 inhibitor; exhibits anticancer and antimalarial activity | |
| 1368 | Geldanamycin |
| Selective Hsp90 inhibitor | |
| 1629 | Herbimycin A |
| Hsp90 inhibitor. Also Src family kinase inhibitor | |
| 1589 | Radicicol |
| Hsp90 inhibitor. Antifungal antibiotic | |
Other |
|
| Cat. No. | Product Name / Activity |
| 5480 | KRIBB11 |
| HSF1 inhibitor | |
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of "client" proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of co-chaperones/accessory proteins (e.g. Hop, cdc37).
Hsp90 has been shown to interact with >100 proteins and some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors), transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the Hsp90β isoform is constitutively expressed whereas the Hsp90α isoform is expressed under stress conditions. Hsp90 plays an important role in some tumor cell types by stabilizing mutated oncogenic proteins.
Literature for Hsp90
Tocris offers the following scientific literature for Hsp90 to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
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Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Hsp90 Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
|
Hsp90α Class A Member 1 |
Human | HSP90AA1 | NM_005348 | P07900 |
| Mouse | Hsp90aa1 | NM_010480 | P07901 | |
| Rat | Hsp90aa1 | NM_031098 | Q63644 | |
|
Hsp90α Class A Member 2 |
Human | HSP90AA2 | NM_001040141 | Q14568 |
|
Hsp90α Class B Member 1 |
Human | HSP90AB1 | NM_007355 | P08238 |
| Mouse | Hsp90ab1 | NM_008302 | P11499 | |
| Hsp90β Member 1 | Human | HSP90B1 | NM_003299 | P14625 |
| Mouse | Hsp90b1 | NM_011631 | P08113 |
Our Cell Cycle and DNA Damage Research Guide highlights over 750 products for cell cycle and DNA damage research.
Request copyRequest PDFWritten by Anthony H.V. Schapira
Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD.
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