Histone Peptides
Histones are the core components of the nucleosome, the building block of eukaryotic chromatin. Post-translational modifications on the histone N-termini are involved in regulating gene transcription. Histone peptides can be used as substrates for histone methyltransferase/demethylase enzymes.
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Literature for Histone Peptides
Tocris offers the following scientific literature for Histone Peptides to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.
Our Epigenetics review gives an overview of the development of chemical probes for epigenetic targets, and discusses their biological effects.
Request copyRequest PDFTaken from the Cancer Product Guide Edition 3
Our Epigenetics in Cancer poster summarizes the main epigenetic targets in cancer, and highlights chemical compounds for the inhibition of these targets.
Request copyDownload PDFWritten by Adam P. Cribbs et al.
Our Rheumatoid Arthritis poster summarizes the disease pathology and highlights some of the epigenetic modifications associated with the condition.
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