Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSTING Degrader SP23
Description: Selective STING Degrader (PROTAC®)
Chemical Name: (2E)-N1-[6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-N4-[4-[[(5-nitro-2-furanyl)carbonyl]amino]phenyl]-2-butenediamide
Purity: ≥98% (HPLC)
Biological Activity for STING Degrader SP23
STING Degrader SP23 is a selective stimulator of interferon gene (STING) Degrader (PROTAC®; DC50 = 3.2 μM). Comprises the STING inhibitor (C-170), joined by a linker to a CRBN ligand Pomalidomide (Cat. No. 6302). It does not degrade JAK2, STAT3, PI 3-K, AKT and TLR4 in THP-1 cells. STING Degrader SP23 dose dependently reduces the levels of IFN-β, IL-6, and CXCL10 triggered by cGAMP in THP-1 cells; it also modulates the downstream signals of the STING signaling pathway in vivo. STING Degrader SP23 has high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model.
Negative control STING Degrader N-Me-SP23 (Cat. No. 8054) and STING/TMEM173 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF6516 and NBP3-18816.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Technical Data for STING Degrader SP23
| M. Wt | 699.68 |
| Formula | C34H33N7O10 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2762552-74-7 |
| PubChem ID | 164886634 |
| InChI Key | TXNQXRGOKABDOB-FOCLMDBBSA-N |
| Smiles | O=C1C2=C(NCCCCCCNC(/C=C/C(NC3=CC=C(C=C3)NC(C4=CC=C(N(=O)=O)O4)=O)=O)=O)C=CC=C2C(N1C5C(NC(CC5)=O)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for STING Degrader SP23
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 69.97 | 100 |
Preparing Stock Solutions for STING Degrader SP23
The following data is based on the product molecular weight 699.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.43 mL | 7.15 mL | 14.29 mL |
| 5 mM | 0.29 mL | 1.43 mL | 2.86 mL |
| 10 mM | 0.14 mL | 0.71 mL | 1.43 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.29 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for STING Degrader SP23
References for STING Degrader SP23
References are publications that support the biological activity of the product.
Liu et al (2022) Novel CRBN-recruiting proteolysis-targeting chimeras as degraders of stimulator of interferon genes with in vivo anti- inflammatory efficacy. J.Med.Chem. 65 6593 PMID: 35452223
If you know of a relevant reference for STING Degrader SP23, please let us know.
View Related Products by Target
Keywords: STING Degrader SP23, STING Degrader SP23 supplier, STINGDegraderSP23, stimulator, of, interferon, gene, STING, PROTAC, PROTACs, degrader, degraders, degrades, anti-inflammatory, CRBN, cereblon, SP23, STING-Dependent, Signaling, Other, Degraders, 8053, Tocris Bioscience
Citations for STING Degrader SP23
Citations are publications that use Tocris products.
Currently there are no citations for STING Degrader SP23. Do you know of a great paper that uses STING Degrader SP23 from Tocris? Please let us know.
Reviews for STING Degrader SP23
There are currently no reviews for this product. Be the first to review STING Degrader SP23 and earn rewards!
Have you used STING Degrader SP23?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia