Alcohol Dehydrogenases
Mammalian alcohol dehydrogenases are a family of enzymes which catalyze the oxidation of alcohols into aldehyde or ketones, with the aid of a co-enzyme, NAD+. In humans, there are five classes (I-V) of alcohol dehydrogenases, encoded by at least seven different genes.
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Mammalian alcohol dehydrogenases are a family of enzymes which catalyze the oxidation of alcohols into aldehyde or ketones, with the aid of a co-enzyme, NAD+. Members of this family also metabolize retinol and hydroxysteroids. In humans, there are five classes (I-V) of alcohol dehydrogenases, encoded by at least seven different genes. The primary hepatic enzyme is alcohol dehydrogenase 1, a class I enzyme, which has A, B and C subunits (encoded by the ADH1A, ADH1B and ADH1C genes respectively), and catalyzes the conversion of ethanol to acetaldehyde.
External sources of pharmacological information for Alcohol Dehydrogenases :
Alcohol Dehydrogenase Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| ADH1A | Human | ADH1A | NM_000667 | M12963 |
| Mouse | Adh1 | NM_007409 | P00329 | |
| Rat | Adh1 | NM_019286 | P06757 | |
| ADH1B | Human | ADH1B | NM_000668 | AF153821 |
| ADH1C | Human | ADH1C | NM_000669 | M12272 |
| ADH4 | Human | ADH4 | NM_000670 | M15943 |
| Mouse | Adh4 | NM_011996 | Q496S1 | |
| Rat | Adh4 | NM_017270 | Q64563 | |
| ADH5 | Human | ADH5 | NM_000671 | M29872 |
| Mouse | Adh5 | NM_007410 | Q6P513 | |
| Rat | Adh5 | NM_001126120 | P12711 | |
| ADH6 | Human | ADH6 | NM_000672 | AK092768 |
| ADH7 | Human | ADH7 | NM_000673 | X76342 |
| Mouse | Adh7 | NM_009626 | Q64437 | |
| Rat | Adh7 | NM_134329 | P41682 |