主页 / 药理学 / Enzymes / Cyclases

Cyclases

The cyclase enzymes, adenylyl cyclase and guanylyl cyclase, convert ATP and GTP to cAMP and cGMP respectively, plus pyrophosphate. These enzymes are important in the production of second messenger molecules and so have a vital role in signal transduction in a variety of physiological processes.

Targets
Enzyme Data

Cyclase Target Files

Related Targets

    Properties of Adenylyl Cyclases

    Subtype Endogenous Activators Endogenous Inhibitors
    AC1 Ca2+/Calmodulin
    PKC-evoked phosphorylation     		Gαi
    AC2 Gβγ
    PKC-evoked phosphorylation     		-
    AC3 Ca2+/Calmodulin
    PKC-evoked phosphorylation     		Gαi
    CaMKII-evoked phosphorylation
    AC4 Gβγ PKC-evoked phosphorylation
    AC5 PKC-evoked phosphorylation Gαi
    Ca2+
    PKA-evoked phosphorylation
    AC6 - Gαi
    Ca2+
    PKA-evoked phosphorylation
    PKC-evoked phosphorylation
    AC7 PKC-evoked phosphorylation -
    AC8 Ca2+ -
    AC9 - Ca2+/calcineurin

    References

    Alexander et al (2008) Guide to receptors and channels (GRAC) 3rd edn. Br.J.Pharmacol. 153 S176.