Cytokine Receptors

Cytokine receptors are a large family of receptors that are grouped into six categories: type I, type II, immunoglobulin superfamily, tumor necrosis factor family, chemokine and TGF-β receptors.

1. Type I cytokine receptors: include the IL-2 receptor, growth hormone receptor and erythropoietin receptor, are linked to JAK tyrosine kinases.
2. Type II cytokine receptors: include interferon receptors are also linked to JAK tyrosine kinases.
3. Immunoglobulin superfamily receptors: also classed as cell adhesion molecules, and family members include the IL-1 and IL-18 receptors.
4. The tumor necrosis factor family: also known as death receptors as they have a role in the extrinsic apoptotic pathway.
5. Chemokine receptors: G-protein-coupled receptors that have a role in innate and adaptive immunity.
6. TGF-β receptors: serine/threonine kinase-coupled receptors with a role in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death.

External sources of pharmacological information for Cytokine Receptors :

• BJP Guide

Cytokine Receptor Gene Data