Diacylglycerol Kinases

Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKα, DGKβ, DGKγ, DGKδ, DGKε, DGKζ, DGKη, DGKθ, DGKι and DGKκ) that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C′-terminal catalytic domain, two cysteine-rich Zn²⁺-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies.

DGKs are widely distributed throughout mammalian tissues and different isozymes have different subcellular localizations; some are cytosolic (for example DGKα), some are membrane-bound (for example DGKγ is associated with the Golgi membrane) and some are nuclear (for example DGKζ). DGKs have diverse biological roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular responses to extracellular stimuli.

External sources of pharmacological information for Diacylglycerol Kinases :

• BJP Guide

Diacylglycerol Kinase Gene Data