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Submit Review1-Methylpsilocin
说明： Potent and selective 5-HT2C agonist
化学名： 3-[2-(Dimethylamino)ethyl]-1-methylindol-4-ol
纯度： ≥99% (HPLC)
生物活性 for 1-Methylpsilocin
1-Methylpsilocin is a potent and selective 5-HT2C agonist (IC50 values are 12 and 633 nM for 5-HT2C and 5-HT2A receptors respectively). Displays high affinity for the 5-HT2B receptor (Ki = 38 nM) but acts as an inverse agonist. Active in vivo; inhibits scratching in a mouse model of OCD.
技术数据 for 1-Methylpsilocin
| 分子量 | 218.29 |
| 公式 | C13H18N2O |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1465-16-3 |
| PubChem ID | 44404883 |
| InChI Key | MZZRFEIDRWKTKJ-UHFFFAOYSA-N |
| Smiles | OC1=C2C(N(C)C=C2CCN(C)C)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for 1-Methylpsilocin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 21.83 | 100 | |
| ethanol | 2.18 | 10 |
制备储备液 for 1-Methylpsilocin
以下数据基于产品分子量 218.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.58 mL | 22.91 mL | 45.81 mL |
| 5 mM | 0.92 mL | 4.58 mL | 9.16 mL |
| 10 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.92 mL |
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产品说明书 for 1-Methylpsilocin
参考文献 for 1-Methylpsilocin
参考文献是支持产品生物活性的出版物。
Sard et al (2005) SAR of psilocybin analogs: discovery of a selective 5-HT2C agonist. Bioorg.Med.Chem.Letts. 15 4559
If you know of a relevant reference for 1-Methylpsilocin, please let us know.
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关键词: 1-Methylpsilocin, 1-Methylpsilocin supplier, Potent, selective, 5-HT2C, agonists, Serotonin, Receptors, 3017, Tocris Bioscience
1 篇 1-Methylpsilocin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 1-Methylpsilocin 的部分引用包括：
Halberstadt et al (2011) Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice. J.Psychopharmacol. 25 1548 PMID: 21148021
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.