5-HT2C Receptors
Serotonin 5-HT2C receptors, previously known as 5-HT1C receptors, are located primarily in the choroid plexus, cortex, limbic system and basal ganglia. 5-HT2C receptors play a role in CSF volume regulation, thermoregulation, penile erection and anxiety.
5-HT2C Receptor Agonists |
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|---|---|
| Cat. No. | Product Name / Activity |
| 3041 | CP 809101 hydrochloride |
| Potent and selective 5-HT2C agonist | |
| 3017 | 1-Methylpsilocin |
| Potent and selective 5-HT2C agonist | |
| 0941 | MK 212 hydrochloride |
| 5-HT2C agonist | |
| 5755 | PF 04479745 |
| Potent and selective 5-HT2C agonist | |
| 1854 | Ro 60-0175 fumarate |
| Potent, selective 5-HT2C agonist | |
| 0925 | SCH 23390 hydrochloride |
| 5-HT2C agonist; also potent dopamine D1-like antagonist and Kir3 channel blocker | |
| 1801 | WAY 161503 hydrochloride |
| Potent and selective 5-HT2C agonist | |
5-HT2C Receptor Antagonists |
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| Cat. No. | Product Name / Activity |
| 0444 | Clozapine |
| 5-HT2A and 5-HT2C antagonist; also dopamine antagonist | |
| 1644 | Mesulergine hydrochloride |
| 5-HT2A and 5-HT2C antagonist; also D2-like partial agonist | |
| 1050 | RS 102221 hydrochloride |
| Selective 5-HT2C antagonist | |
| 1661 | SB 206553 hydrochloride |
| Potent and selective 5-HT2B and 5-HT2C antagonist; orally active | |
| 2901 | SB 242084 |
| Selective 5-HT2C antagonist; brain penetrant | |
Serotonin 5-HT2C receptors, previously known as 5-HT1C receptors, are located primarily in the choroid plexus, cortex, limbic system and basal ganglia. 5-HT2C receptors play a role in CSF volume regulation, thermoregulation, penile erection and anxiety. The human 5-HT2C receptor gene has been localized to chromosome X (Xq24).
External sources of pharmacological information for 5-HT2C Receptors :
Literature for 5-HT2C Receptors
Tocris offers the following scientific literature for 5-HT2C Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes.
Request copyRequest PDFWritten by P. Skolnich et al
Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder.
Request copyDownload PDFWritten by Anthony H.V. Schapira
Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD.
Request copyDownload PDF